109-11-5Relevant articles and documents
In vitro inhibition studies of phytoene desaturase by bleaching ketomorpholine derivatives
Sandmann, Gerhard,Mitchell, Glynn
, p. 138 - 141 (2001)
The herbicidal activities of homochiral steroisomeric 5-methyl-2-(3-trifluoromethylbenzyl)-3-ketomorpholine derivatives were investigated in vitro as inhibitors of phytoene desaturase, a key enzyme in carotenoid biosynthesis. It was demonstrated that ketomorpholines are classical bleaching compounds which directly inhibit phytoene desaturase, accumulating phytoene at the expense of colored carotenoids. Ketomorpholines interact with phytoene desaturase in a noncompetitive manner with respect to phytoene. A structure-activity investigation for in vitro inhibition of phytoene desaturase activity revealed that the relative and absolute stereochemistry is important for optimum inhibition for the 5-methyl derivatives, and that the distance of the phenyl group from the ketomorpholine ring is critical for the inhibitory potential. The average herbicidal score on 7 weeds and the in vitro I50 values related very well with the exception of two compounds. It was postulated that the discrepancies may possibly occur through modification in plants to compounds that are either more or less active herbicides.
Method for preparing 3-morpholone
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Paragraph 0046; 0048; 0054; 0056, (2018/10/11)
The invention provides a method for preparing 3-morpholone. The method comprises the steps that halogen hydride removing is carried out on 2-halogenated ethylamine hydrohaloate under the condition oforganic solvent existing, an obtained reaction system and 2-glycollic acid ester are mixed and then subjected to amine ester exchange reaction to obtain 2-(2-hydroxyacetamido) halothane; ring closurereaction is carried out on the 2-(2-hydroxyacetamido) halothane under the condition of alkali reagent and organic solvent existing to obtain the 3-morpholone. The method for preparing the 3-morpholonehas the advantages that the technology side reaction is less, the product purification is convenient; the operation is simple, the safety is high, the method is environmentally friendly; raw materials are obtained easily, the price is low; the product yield is high (reaches 75.5%), the purity is high (reaches 99% or above), the method is suitable for the industrialized batch production, and the industrialized prospect is good.
Supported Gold Nanoparticles for Efficient α-Oxygenation of Secondary and Tertiary Amines into Amides
Jin, Xiongjie,Kataoka, Kengo,Yatabe, Takafumi,Yamaguchi, Kazuya,Mizuno, Noritaka
supporting information, p. 7212 - 7217 (2016/07/06)
Although the α-oxygenation of amines is a highly attractive method for the synthesis of amides, efficient catalysts suited to a wide range of secondary and tertiary alkyl amines using O2as the terminal oxidant have no precedent. This report describes a novel, green α-oxygenation of a wide range of linear and cyclic secondary and tertiary amines mediated by gold nanoparticles supported on alumina (Au/Al2O3). The observed catalysis was truly heterogeneous, and the catalyst could be reused. The present α-oxygenation utilizes O2as the terminal oxidant and water as the oxygen atom source of amides. The method generates water as the only theoretical by-product, which highlights the environmentally benign nature of the present reaction. Additionally, the present α-oxygenation provides a convenient method for the synthesis of18O-labeled amides using H218O as the oxygen source.