109-51-3

Basic information

• Product Name: PENTANAMIDINE
• Synonyms: pentanimidamide(SALTDATA: HCl);PentanoaMidine;ValeraMidine
• CAS NO: 109-51-3
• Molecular Formula: C₅H₁₂N₂
• Molecular Weight: 100.16
• Mol File: 109-51-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 141.9°C at 760 mmHg
• Flash Point: 39.6°C
• Appearance: /
• Density: 0.95g/cm³
• Vapor Pressure: 5.72mmHg at 25°C
• Refractive Index: 1.467
• CAS DataBase Reference: PENTANAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: PENTANAMIDINE(109-51-3)
• EPA Substance Registry System: PENTANAMIDINE(109-51-3)

Safety Data

• Hazardous Substances Data: 109-51-3(Hazardous Substances Data)

Usage

General Description

Pentamidine is an aromatic diamidine compound that is used as an antiprotozoal and antimicrobial agent. It is an effective treatment for Pneumocystis jiroveci pneumonia in patients with AIDS and is also used to prevent and treat a variety of protozoal infections, including leishmaniasis, trypanosomiasis, and malaria. Pentamidine works by interfering with the growth and reproduction of these protozoa, thereby helping to eradicate the infections. However, it can cause severe side effects, including kidney damage, pancreatitis, and irregular heartbeats, so it is typically reserved for patients who have failed other treatments or cannot tolerate other medications. Pentamidine is typically administered through injection or inhalation, and its use requires close monitoring for potential adverse effects.

InChI:InChI=1/C5H12N2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H3,6,7)

Upstream product

• 110-59-8 pentanonitrile 
• 39800-84-5 propamidine 
• 107-12-0 propiononitrile 

Downstream Products

• 106-97-8 n-butane 
• 1313233-75-8 methyl 2-butyl-1-[(2'-cyanobiphenyl-4-yl)methyl]-4-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid 
• 1313233-73-6 4'-{[2-butyl-4-(4-fluorophenyl)-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide 
• 1313233-74-7 2-butyl-1-{(2'-cyanobiphenyl-4-yl)methyl}-4-(4-fluorophenyl)-1H-imidazole-5-carboxylic acid 
• 1313233-72-5 4'-[{2-butyl-4-(4-fluorophenyl)-5-(hydroxymethyl)-1H-imidazol-1-yl}methyl]biphenyl-2-carbonitrile 
• 1313233-71-4 4'-[{2-butyl-4-(4-fluorophenyl)-5-formyl-1H-imidazol-1-yl}methyl]biphenyl-2-carbonitrile 
• 1313233-70-3 2-butyl-4-(4-fluorophenyl)-1H-imidazole-5-carbaldehyde 
• 1313233-69-0 {2-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl}methanol 
• 1313233-49-6 3-[4'-[{2-butyl-4-(4-fluorophenyl)-5-(hydroxymethyl)-1H-imidazol-1-yl}methyl]biphenyl-2-yl]-1,2,4-oxadiazol-5(4H)-one 
• 1313233-68-9 2-butyl-4-(4-fluorophenyl)-1H-imidazole 
• 158365-99-2 2-butyl-5-chloro-1H-imidazole 
• 83857-96-9 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde 

Relevant articles and documents

Dual antagonist of angiotensin II receptor and endothelin receptor

The invention relates to dual antagonists of an angiotensin II receptor and an endothelin receptor. Specifically, the invention provides a compound represented by a formula I and a preparation method thereof. The compound can be used for treating diseases