109012-93-3Relevant academic research and scientific papers
Asymmetric synthesis of α-aryl amino acids; Aryne-mediated diastereoselective arylation
Jones, Elizabeth P.,Jones, Peter,Barrett, Anthony G. M.
supporting information; experimental part, p. 1012 - 1015 (2011/05/15)
An aryne-mediated α-arylation reaction of Schoellkopf's bis-lactim ether is described. Arynes were generated via an ortho-lithiation approach, affording syn-arylated products in up to 94:6 dr with moderate to good yields and excellent regioselectivities. Hydrolysis provided a variety of substituted arylglycines containing a range of functional groups without racemization.(Figure Presented)
