109057-09-2

Usage

Uses

Used in Pharmaceutical Applications:
1-((Trifluoromethyl)sulphonyl)-1H-pyrrole is used as a building block for the development of novel drugs in the pharmaceutical industry. Its strong electron-withdrawing properties and ability to form stable complexes with transition metal ions make it a promising candidate for creating new therapeutic agents.
Used in Agrochemical Applications:
In the agrochemical industry, 1-((Trifluoromethyl)sulphonyl)-1H-pyrrole is used as a key component in the creation of new pesticides. Its reactivity and electronegativity allow for the development of compounds that can effectively target and control pests, thereby enhancing crop protection and yield.
However, it is important to note that the reactivity and potential toxicity of 1-((Trifluoromethyl)sulphonyl)-1H-pyrrole also make it a subject of continued research for safety and environmental concerns. This is crucial to ensure that any applications of 1-((Trifluoromethyl)sulphonyl)-1H-pyrrole are carried out responsibly and with minimal negative impact on human health and the environment.

Upstream product

• 109-97-7 pyrrole 
• 29540-81-6 1-(trifluoromethylsulfonyl)-1H-imidazole 
• 335-05-7 Trifluoromethanesulfonyl fluoride 

Relevant academic research and scientific papers

Synthesis and cycloaddition of N-substituted pyrroles with polyfluorinated substituents

Reactions of N-pyrrolylpotassium with fluorinated electrophiles yielded N-substituted pyrroles containing polyfluoroalkyl, polyfluoroalkenyl, polyfluoroalkylsulfonyl, and polyfluoroaryl substituents. N-Polyfluoro- substituted pyrroles did not isomerize at ≥100°C; they were found to be reactive in [4+2] cycloaddition reactions with perfluorobut-2-yne.

Electrophilic Hydrogen-Deuterium Exchange of Some Deactivated Pyrroles

The rate coefficients and partial rate factors for the hydrogen-deuterium exchange of some 1-substituted pyrroles (1-substituents= -COCH3, -COC6H5, -SO2CH3, -SO2CF3, -N(1+)(CH3), -N(1+)H(CH3)2, -SO2C6H5) in deuterated trifluoroacetic acid have been determined.In all cases the rate of exchange is faster at the 2-position.Similary, the hydrogen-deuterium exchange of some pyrroles with electron withdrawing substituents in the 2-position indicate a relative reactivity of 4->5->3-position with the selectivity being greatest for the more electron withdrawing groups.A nitro group in the 3-position of pyrrole shows a relative reactivity of 5->2->4-position for the hydrogen-deuterium exchange in deuterated trifluoroacetic acid.A linear correlation is observed for the log of the rate coefficient of the hydrogen-deuterium exchange at the 4-position of some 2-substituted pyrroles and the difference in the calculated energy of formation of the pyrrole and the corresponding 4-deuterated cation.