1090807-72-9Relevant academic research and scientific papers
Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines
Cheeseman, Matthew D.,Faisal, Amir,Rayter, Sydonia,Barbeau, Olivier R.,Kalusa, Andrew,Westlake, Maura,Burke, Rosemary,Swan, Michael,Van Montfort, Rob,Linardopoulos, Spiros,Jones, Keith
supporting information, p. 3469 - 3474 (2014/07/22)
The metal-dependent phosphatase PPM1D (WIP1) is an important oncogene in cancer, with over-expression of the protein being associated with significantly worse clinical outcomes. In this communication we describe the discovery and optimization of novel 2,4
FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE
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Page/Page column 34; 35, (2014/03/25)
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts, hydrates and solvates thereof for use in the treatment of cancer:
