109090-53-1

Basic information

• Product Name: 2-(4-ethoxyphenylamino)-N'-(4-nitrobenzylidene)acetohydrazide
• CAS NO: 109090-53-1
• Molecular Weight: 342.354
• Mol File: 109090-53-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-ethoxyphenylamino)-N'-(4-nitrobenzylidene)acetohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-ethoxyphenylamino)-N'-(4-nitrobenzylidene)acetohydrazide(109090-53-1)
• EPA Substance Registry System: 2-(4-ethoxyphenylamino)-N'-(4-nitrobenzylidene)acetohydrazide(109090-53-1)

Safety Data

• Hazardous Substances Data: 109090-53-1(Hazardous Substances Data)

Upstream product

• 156-43-4 4-Ethoxyaniline 
• 100133-39-9 2-[(4-ethoxyphenyl)amino]acetohydrazide 
• 555-16-8 4-nitrobenzaldehdye 
• 29904-09-4 2-(4-ethoxyphenylamino)acetamide 

Relevant articles and documents

Synthesis and evaluation of some novel methylene-bridged aryl semicarbazones as potential anticonvulsant agents

A series of aryl semicarbazones containing a methylene bridge in their skeleton were synthesized as anticonvulsant agents. The strategy of introducing a methylene bridge was to increase the flexibility of the structures because of sp3 hybridization. Pharmacological evaluations of the compounds were performed by determination of their effects on pentylenetetrazole-induced seizure parameters and neurotoxicity in mice. The statistical analysis indicated that most of the synthesized compounds showed significant anticonvulsant activity in comparison with the control group. No remarkable neurotoxicity was observed in rotorod test. A QSAR study was performed using multiple linear regressions. The results of the QSAR study confirmed that the compounds with Br at para position of these new derivatives are more potent than para-ethoxy series. Springer Science+Business Media, LLC 2011.