109115-05-1

Usage

Uses

Used in Pharmaceutical Industry:
2-(Chloromethyl)-4-fluoro-1-nitrobenzene is used as an intermediate in the synthesis of various pharmaceuticals for its potential biological activities, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
2-(Chloromethyl)-4-fluoro-1-nitrobenzene also serves as a key intermediate in the production of agrochemicals, where it is utilized for the synthesis of pesticides and other agricultural chemicals to improve crop protection and yield.
Used in Organic Chemistry:
2-(Chloromethyl)-4-fluoro-1-nitrobenzene is used as a building block in organic chemistry for the production of other organic compounds, showcasing its versatility and importance in the synthesis of a wide range of chemical products.

Upstream product

• 287121-32-8 (5-Fluoro-2-nitrophenyl)-methanol 

Downstream Products

• 109114-86-5 5-(5-Fluoro-2-nitro-benzyl)-imidazolidine-2,4-dione 
• 82420-41-5 5-Fluoro-2-nitrophenylalanine Hydrochloride 
• 82420-38-0 Ethyl 2-Acetamido-2-(5'-fluoro-2'-nitrobenzyl)malonate 

Relevant academic research and scientific papers

ARYL - /HETEROARYL - CYCLOHEXENYL - TETRAAZABENZO [E] AZULENES AS VASOPRESSIN ANTAGONISTS

The present invention is concerned with aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes of formula I wherein R1, R2 and R3 are as described herein. The compounds according to the invention act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.

DIHYDROPYRIDINE DERIVATIVES

The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, phenyl, (1-5C)heteroaryl R2, R3 are independently (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (24C)alkenyloxy, (2-4C)alkynyloxy, halogen X is SO2, CH2, C(O) or X is absent R4 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2-6C)heterocycloalkyl(14C)alkyl, (6-1 OC)aryl, (6-10C)aryl(1-4C)alkyl, (1-9C)heteroaryl or (1-9C)heteroaryl(14C)alkyl. The compounds are useful for the treatment of fertility disorders.

DIHYDROPYRIDINE DERIVATIVES

The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, phenyl, (1-5C)heteroaryl R2, R3 are independently (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (2-4C)alkenyloxy, (2-4C)alkynyloxy, halogen X is SO2, CH2, C(O) or X is absent R4 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2-6C)heterocycloalkyl(1-4C)alkyl, (6-1 OC)aryl, (6-10C)aryl(1-4C)alkyl, (1-9C)heteroaryl or (1-9C)heteroaryl(1-4C)alkyl. The compounds are useful for the treatment of fertility disorders.