109152-46-7

Upstream product

• 17199-29-0 (S)-Mandelic acid 
• 626-56-2 3-Methylpiperidine 

Downstream Products

• 1191044-71-9 N-[((2S,5S)-1-{[3-fiuoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-5-(trifluoromethyl)-2-pyridinamine 
• 1191044-58-2 5-bromo-N-({1-[(3-fluoro-2-methoxyphenyl)carbonyl]-5-methylpiperidin-2-yl}methyl)pyridin-2-amine 
• 1191044-78-6 5-chloro-N-[((2S,5S)-1-{[3-fluoro-2-(methyloxy)phenyl]carbonyl}-5-methyl-2-piperidinyl)methyl]-2-pyridinamine 
• 474-08-8 demissidine 
• 1430078-28-6 3-(tert-butyldiphenylsilyloxy)demissidine 
• 1430078-26-4 C₄₄H₆₅NO₄SSi 
• 1430078-24-2 ((2aS,4S,6aS,6bS,8aS,8bR,9S,9aR,12S,14aS,15aS,15bR)-4-((tert-butyldimethylsilyl)oxy)-6a,8a,12-trimethyldocosahydro-1H-naphtho[2',1':4,5]indeno[1,2-b]indolizin-9-yl)methanol 
• 1430078-22-0 C₄₅H₆₅NO₃Si 
• 1430078-20-8 C₄₅H₆₁NO₃Si 
• 1430078-16-2 C₄₅H₆₃NO₃Si 
• 1268818-47-8 1,1-dimethylethyl (2S,5S)-5-methyl-2-{[(phenylmethyl)amino]methyl}-1-piperidinecarboxylate 
• 1268817-70-4 2-(2-{[(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinyl]carbonyl}-6-methyl-3-pyridinyl)pyrimidine 
• 1268817-69-1 (2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methylpiperidine 
• 1268817-68-0 1,1-dimethylethyl (2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinecarboxylate 

Relevant academic research and scientific papers

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis

A high-throughput screen (HTS) was undertaken against the respiratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberculosis (Mtb). The 11000 compounds were selected for the HTS based on the known phenothiazine Ndh inhibitors, trifluoperazine and thioridazine. Combined HTS (11000 compounds) and in-house screening of a limited number of quinolones (50 compounds) identified ～100 hits and four distinct chemotypes, the most promising of which contained the quinolone core. Subsequent Mtb screening of the complete in-house quinolone library (350 compounds) identified a further ～90 hits across three quinolone subtemplates. Quinolones containing the amine-based side chain were selected as the pharmacophore for further modification, resulting in metabolically stable quinolones effective against multi drug resistant (MDR) Mtb. The lead compound, 42a (MTC420), displays acceptable antituberculosis activity (Mtb IC50 = 525 nM, Mtb Wayne IC50 = 76 nM, and MDR Mtb patient isolates IC50 = 140 nM) and favorable pharmacokinetic and toxicological profiles.

5-METHYL-PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF SLEEP DISORDER

This invention relates to heteroaryloxy 5-methyl substituted piperidine derivatives and their use as pharmaceuticals.

PIPERIDINE DERIVATIVES USED AS OREXIN ANTAGONISTS

This invention relates to he teroarylamine methyl substituted piperidine derivatives (I) and their use as antagonists of human orexin.

PYRIDINE DERIVATIVES USED TO TREAT OREXIN RELATED DISORDERS

This invention relates to pyridinamine methyl substituded piperidinyl derivatives I and their use as pharmaceuticals.