109153-67-5Relevant articles and documents
Novel Stable Bioactivated Cyclophosphamide Derivatives for Selective Cancer Chemotherapy, Synthesis of Aldophosphamide Acetal-glycosides and Their Glycoconjugates
Tietze, Lutz F.,Fischer, Roland,Beller, Mathias,Seele, Rainer
, p. 151 - 157 (2007/10/02)
Stimulation of tumor cell glycolysis in vivo leads to an increase of lactic acid formation and thus a decrease of pH in malignant tissue compared with a normal cell population.The difference in pH may be used to cleave a nontoxic prodrug selectively in a
SYNTHESIS OF ACETAL-α-GLUCOSIDES. A STEREOSELECTIVE ENTRY INTO A NEW CLASS OF COMPOUNDS
Tietze, Lutz F.,Fischer, Roland,Guder, Hans J.,Goerlach, Ada,Neumann, Manfred,Krach, Thomas
, p. 177 - 194 (2007/10/02)
Acetal-glycosides are a new class of compounds, which became of special interest as enzyme inhibitors and cytostatics for the treatment of cancer.In a highly stereoselective glucosidation, acetyl-protected acetal-α-glucosides such as methoxymethyl 2,3,4,6