109155-32-0Relevant academic research and scientific papers
Synthesis, biological evaluation, and molecular simulation of chalcones and aurones as selective MAO-B inhibitors
Morales-Camilo, Nicole,Salas, Cristian O.,Sanhueza, Claudia,Espinosa-Bustos, Christian,Sepúlveda-Boza, Silvia,Reyes-Parada, Miguel,Gonzalez-Nilo, Fernando,Caroli-Rezende, Marcos,Fierro, Angélica
, p. 685 - 695 (2015)
A series of chalcones and aurones were synthesized and evaluated in vitro as monoamine oxidase inhibitors (MAOi). Our results show that aurones, which had not been previously reported as MAOi, are MAO-B inhibitors. Thus, both families inhibited selectively the B isoform of MAO in the micromolar range, offering novel scaffolds for the design of new and potent MAO inhibitors. The main structural requirements for their activity were characterized with the aid of 3D-QSAR and docking studies.
Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication
Shen, Xianyan,Zhou, Qiang,Xiong, Wei,Pu, Wenchen,Zhang, Wei,Zhang, Guolin,Wang, Chun
, p. 4822 - 4829 (2017/07/17)
Herein, we report a synthetic method with improved selectivity for 5-substituted flavonols via the Algar-Flynn-Oyamada reaction (AFO), by using of sodium carbonate/hydrogen peroxide A series of 5-substituted flavonols was obtained with moderate to high yields. The mechanism of the AFO reaction was elucidated. LCMS analysis and in situ 1H NMR analysis indicated that the epoxide was involved in the transformation from chalcone to flavonol and/or aurone under alkaline base/peroxide conditions.
1H and 13C NMR spectral assignments of 2′-hydroxychalcones
Yong, Yeonjoong,Ahn, Seunghyun,Hwang, Doseok,Yoon, Hyuk,Jo, Geunhyeong,Kim, Young Hwa,Kim, Sang Ho,Koh, Dongsoo,Lim, Yoongho
, p. 364 - 370 (2013/07/28)
Chalcones are of interest to medicinal chemists because their structures can be easily modified with various functional groups. The syntheses and biological activities of chalcones from natural sources are well known. In this study, 24 2′-hydroxychalcones bearing methoxy substituents were synthesized, among which five are new. The NMR data for all synthesized chalcones are described for the first time. The complete assignments of the 1H and 13C NMR data can be used for the identification of newly discovered and widely isolated, synthesized chalcones. Copyright
