1091585-31-7

Basic information

• Product Name: (2R,5S)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(4'-chloro)-benzoate
• Synonyms: (2R,5S)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(4'-chloro)-benzoate
• CAS NO: 1091585-31-7
• Molecular Weight: 409.85
• Mol File: 1091585-31-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,5S)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(4'-chloro)-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,5S)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(4'-chloro)-benzoate(1091585-31-7)
• EPA Substance Registry System: (2R,5S)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(4'-chloro)-benzoate(1091585-31-7)

Safety Data

• Hazardous Substances Data: 1091585-31-7(Hazardous Substances Data)

Upstream product

• 96472-73-0 bis-TMS-N-acetylcytosine 

Downstream Products

• 134678-17-4 lamivudine 
• 139757-68-9 (+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine 

Relevant articles and documents

A PROCESS FOR STEREOSELECTIVE SYNTHESIS OF LAMIVUDINE

The present invention discloses a process for stereoselective synthesis of Lamivudine comprising the following steps: (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and (b) deprotecting the intermediate of formula (II) to obtain Lamivudine.