1091605-41-2

Upstream product

• 866488-35-9 (E)-benzyl (4-hydroxy-7-oxooct-5-en-1-yl)carbamate 
• 501-53-1 benzyl chloroformate 

Relevant academic research and scientific papers

Concise asymmetric synthesis of (+)-febrifugine utilizing trans-selective intramolecular conjugate addition

Intramolecular conjugate addition of γ-substituted (E)- α,β-unsaturated ketones with a Lewis acid (BF3· OEt2) selectively afforded trans-2,3-disubstituted piperidine derivatives. Chiral substrates were synthesized by Sharpless asymmetric dihydroxylation of the enamine; the antimalarial compound febrifugine was synthesized from the major product of the conjugate addition reaction. Georg Thieme Verlag Stuttgart.