1091607-95-2Relevant academic research and scientific papers
Antisense oligonucleotides containing conformational constrained 2′,4′-(N-Methoxy)aminomethylene and 2′4′- aminooxymethylene and 2′-O,′-C-aminomethylene bridged nucleoside analogues show improved potency in animal models
Prakash, Thazha P.,Siwkowski, Andrew,Allerson, Charles R.,Migawa, Michael T.,Lee, Sam,Gaus, Hans J.,Black, Chris,Seth, Punit P.,Swayze, Eric E.,Bhat, Balkrishen
experimental part, p. 1636 - 1650 (2010/08/03)
To identify chemistries and strategies to improve the potency of MOE second generation ASOs, we have evaluated gapmer antisense oligonucleotides containing BNAs having N-O bonds. These modifications include AT-MeO-amino BNA, N-Me-aminooxy BNA, 2′,4′-BNAs
N-SUBSTITUTED-AMINOMETHYLENE BRIDGED BICYCLIC NUCLEIC ACID ANALOGS
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Page/Page column 42, (2009/01/24)
Provided herein are bicyeMc nucleosides comprising a substituted amino group in the bridge, oligomeric compounds having at least one of these bi cyclic nucleosides and methods of using the oligomeric compounds. The bicyclic nucleosides comprising a substituted amino group in the bridge are useful for enhancing properties of oligomeric compounds including nuclease resistance, in certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
