1091608-01-3Relevant articles and documents
Antisense oligonucleotides containing conformational constrained 2′,4′-(N-Methoxy)aminomethylene and 2′4′- aminooxymethylene and 2′-O,′-C-aminomethylene bridged nucleoside analogues show improved potency in animal models
Prakash, Thazha P.,Siwkowski, Andrew,Allerson, Charles R.,Migawa, Michael T.,Lee, Sam,Gaus, Hans J.,Black, Chris,Seth, Punit P.,Swayze, Eric E.,Bhat, Balkrishen
, p. 1636 - 1650 (2010)
To identify chemistries and strategies to improve the potency of MOE second generation ASOs, we have evaluated gapmer antisense oligonucleotides containing BNAs having N-O bonds. These modifications include AT-MeO-amino BNA, N-Me-aminooxy BNA, 2′,4′-BNAs
N-SUBSTITUTED-AMINOMETHYLENE BRIDGED BICYCLIC NUCLEIC ACID ANALOGS
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Page/Page column 45-46, (2009/01/24)
Provided herein are bicyeMc nucleosides comprising a substituted amino group in the bridge, oligomeric compounds having at least one of these bi cyclic nucleosides and methods of using the oligomeric compounds. The bicyclic nucleosides comprising a substituted amino group in the bridge are useful for enhancing properties of oligomeric compounds including nuclease resistance, in certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
