1091630-20-4Relevant articles and documents
The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc
Scaffidi, Adrian,Stubbs, Keith A.,Vocadlo, David J.,Stick, Robert V.
experimental part, p. 2744 - 2753 (2009/04/11)
The synthesis of some analogues of O-(2-acetamido-2-deoxy-d-glucopyranosylidene)amino N-phenylcarbamate, PUGNAc, an inhibitor of β-N-acetylglucosaminidases, is described. The analogues were tested against a range of β-N-acetylglucosaminidases to establish any biological activity. As well, the analogues were tested as inhibitors of a uridine diphosphate-N-acetyl-d-glucosamine: polypeptidyl transferase, OGT, a critical protein involved in the post-translational modification of nuclear and cytosolic proteins by N-acetyl-d-glucosamine.