109179-75-1Relevant academic research and scientific papers
ORGANOMANGANESE (II) REAGENTS XII1: AN EFFICIENT ONE-POT PREPARATION OF UNSYMMETRICAL SECONDARY OR TERTIARY ALCOHOLS
Cahiez, G.,Rivas-Enterrios, J.,Granger-Veyron, H.
, p. 4441 - 4444 (1986)
Various unsymmetrical secondary or tertiary alcohols have been prepared in high yields by an efficient one-pot procedure involving the acylation of an organomanganese reagent by an acyl chloride and the addition to the ketone formed of various organometallic compounds (RLi, RMgX, LiAlH4, NaBH4).The complexation of the intermediate ketone by the metallic salts present in the reaction mixture allows to perform the 1-2 addition step under exceptionally mild conditions ( to 20 deg C).
