109201-46-9

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 87512-29-6 2-chloro-6-(methylsulfonyl)pyridine 
• 109-09-1 2-chloropyridine 
• 17200-12-3 lithium 2-(dimethylamino)ethanolate 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Unusual C-6 lithiation of 2-chloropyridine-mediated by BuLi-Me2N(CH2)2OLi. New access to 6-functional-2-chloropyridines and chloro-bis-heterocycles

Formula Presented The reaction of 2-chloropyridine with alkylithium generally results in nucleophilic addition leading to the loss of chlorine atom while exclusive directed ortho metalation is obtained using LDA. Herein it is shown that the BuLi-Me2

2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof: wherein: R1, R2, R3, R4, R5, R6, R7, R8, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

IPSO-SUBSTITUTION REACTIONS OF 2- AND 4-SULFONYLPYRIDINES WITH GRIGNARD REAGENTS

The reactions of 2-sulfonylpyridines with Grignard reagents proceeded via an ionic path to give only the corresponding ipso-substitution products, while 4-sulfonylpyridines afforded mainly a mixture of both the substitution and coupling products on treatment with Grignard reagents.