109202-01-9Relevant academic research and scientific papers
Facile synthesis of 3-substituted thiazolo[2,3-α]tetrahydroisoquinolines
Huang, Sheng-Han,Huang, Wan-Yu,Zhang, Guo-Lun,Yang, Te-Fang
supporting information, (2021/10/20)
It was found that 4-hydroxy-2-butenoic ester (11) could not react with 3,4-dihydro-isoquinoline (4a). Individual addition reactions of γ-mercapto-α,β-unsaturated esters (18) and-unsaturated amide (19) with 3,4-dihydroisoquinolines (4) were carried out under appropriate conditions to provide the corresponding thiazolo[2,3-α]isoquinoline derivatives with good yields (up to 87%) and significant diastereomeric selectivity. The mechanism of the crucial reaction was discussed.
A ONE-STEP PREPARATION OF (E)-4-MERCAPTO-2-BUTENOIC ESTERS AND NITRILES RELATIVE MICHAEL REACTIVITIES IN SIMPLE UNSATURATED SYSTEMS
Bunce, Richard A.,Pierce, Joey D.
, p. 5583 - 5586 (2007/10/02)
A one-step procedure is described for the preparation of (E)-4-mercapto-2-butenoic esters and nitriles in 75-85percent yield.The corresponding ketones could not be isolated due to dimerization of the initially-formed products by a double Michael reaction.
