1092070-65-9Relevant articles and documents
Total synthesis of (-)-2-epi-peloruside A
Smith III, Amos B.,Cox, Jason M.,Furuichi, Noriyuki,Kenesky, Craig S.,Zheng, Junying,Atasoylu, Onur,Wuest, William M.
, p. 5501 - 5504 (2008)
(Chemical Equation Presented) A convergent synthesis of (-)-2-epi-peloruside A has been achieved. Highlights include implementation of multicomponent type I anion relay chemistry (ARC) to unite 2-TBS-1,3-dithiane with two epoxides to construct the eastern hemisphere, a late-stage dithiane union to secure the complete, fully functionalized carbon backbone, and Yamaguchi macrolactonization, which led to (-)-2-epi-peloruside A via an unexpected epimerization at C(2).