1092367-45-7Relevant articles and documents
A rapid access to new fluorinated 1,3-dienes and benzylic fluorides via metathesis on propargylic fluorides
Pujari, Sandip A.,Kaliappan, Krishna P.,Valleix, Alain,Grée, Danielle,Grée, René
, p. 2503 - 2507 (2008)
The cross enyne metathesis reaction of propargylic fluoride (+)-12 with ethylene affords the enantioenriched 1,3-diene (+)-14 having fluorine-containing side chain at 2-position in good yield. Upon Diels-Alder reaction, followed by aromatization, this diene affords the new benzylic fluorides (+)-16 and (+)-17 in high ee values. This new strategy has been successfully extended to the corresponding gem-difluoro diene 21 and benzylic fluorides 23 and 24. Georg Thieme Verlag Stuttgart.