1092379-85-5

Basic information

• Product Name: C₁₇H₂₅NO₂Si
• Synonyms: C₁₇H₂₅NO₂Si
• CAS NO: 1092379-85-5
• Molecular Weight: 303.476
• Mol File: 1092379-85-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₅NO₂Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₅NO₂Si(1092379-85-5)
• EPA Substance Registry System: C₁₇H₂₅NO₂Si(1092379-85-5)

Safety Data

• Hazardous Substances Data: 1092379-85-5(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 323204-69-9 1-benzyl-5-hydroxy-1,5-dihydro-2H-pyrrol-2-one 

Relevant articles and documents

Chemoenzymatic total synthesis and determination of the absolute configuration of (S)-nebracetam

We have developed an asymmetric total synthesis of nebracetam 3 by a chemoenzymatic strategy. Diastereoselective Michael addition of nitromethane to the chiral lactam (S)-9d (>99% ee), which was prepared by lipase-catalyzed kinetic resolution, afforded the Michael product 10d in 99% yield with 86% de. Chemical transformations of 10d including recrystallization furnished the chiral nebracetam 3 and its derivative. The absolute configuration of the chiral (-)-nebracetam was determined to be an (S)-configuration.