1092443-55-4

Basic information

• Product Name: BS194
• Synonyms: BS194;(2S,3S)-3-(7-(benzylaMino)-3-isopropylpyrazolo[1,5-a]pyriMidin-5-ylaMino)butane-1,2,4-triol;1,2,4-Butanetriol, 3-[[3-(1-Methylethyl)-7-[(phenylMethyl)aMino]pyrazolo[1,5-a]pyriMidin-5-yl]aMino]-, (2S,3S)-;(2S,3S)-3-[[3-(1-Methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]-1,2,4-butanetriol
• CAS NO: 1092443-55-4
• Molecular Formula: C₂₀H₂₇N₅O₃
• Molecular Weight: 385.46008
• Mol File: 1092443-55-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BS194(CAS DataBase Reference)
• NIST Chemistry Reference: BS194(1092443-55-4)
• EPA Substance Registry System: BS194(1092443-55-4)

Safety Data

• Hazardous Substances Data: 1092443-55-4(Hazardous Substances Data)

Usage

General Description

"BS194" is a mixture of chemicals used as a food preservative and antimicrobial agent. The main active ingredient in "BS194" is sodium benzoate, which works by preventing the growth of bacteria, mold, and yeast, extending the shelf life of food products. It is commonly used in acidic foods and beverages, such as sodas, fruit juices, and pickles, and is generally recognized as safe (GRAS) by the Food and Drug Administration (FDA) in the United States. However, some studies have raised concerns about potential health risks associated with long-term consumption of sodium benzoate, such as its potential to form benzene, a known carcinogen, when combined with certain ingredients. Therefore, its usage and safety regulations are subject to ongoing discussions and evaluations.

Upstream product

• 771510-32-8 5,7-dichloro-3-iso-propyl-pyrazolo[1,5-a]pyrimidine 
• 1092444-50-2 (R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)but-3-en-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate 
• 1092444-33-1 benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester 
• 1092443-98-5 benzyl-(5-chloro-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)-amine 
• 151521-49-2 4-isopropyl-1 H-pyrazol-5-amine 
• 771510-15-7 2-formyl-3-methylbutanenitrile 
• 625-28-5 Isovaleronitrile 
• 771510-25-9 3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol 
• 1092444-51-3 tert-butyl benzyl(5-(((2S,3S)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate 

Relevant articles and documents

A novel pyrazolo[1,5- a ]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration

Cyclin-dependent protein kinases (CDKs) are central to the appropriate regulation of cell proliferation, apoptosis, and gene expression. Abnormalities in CDK activity and regulation are common features of cancer, making CDK family members attractive targets for the development of anticancer drugs. Here, we report the identification of a pyrazolo[1,5-a]pyrimidine derived compound, 4k (BS-194), as a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9 (IC50 = 3, 30, 30, 250, and 90 nmol/L, respectively). Cell-based studies showed inhibition of the phosphorylation of CDK substrates, Rb and the RNA polymerase II C-terminal domain, down-regulation of cyclins A, E, and D1, and cell cycle block in the S and G2/M phases. Consistent with these findings, 4k demonstrated potent antiproliferative activity in 60 cancer cell lines tested (mean GI50 = 280 nmol/L). Pharmacokinetic studies showed that 4k is orally bioavailable, with an elimination half-life of 178 min following oral dosing in mice. When administered at a concentration of 25 mg/kg orally, 4k inhibited human tumor xenografts and suppressed CDK substrate phosphorylation. These findings identify 4k as a novel, potent CDK selective inhibitor with potential for oral delivery in cancer patients.