1092458-22-4Relevant articles and documents
Stereoselective monofluoromethylation of N-tert-butylsulfinyl ketimines using pregenerated fluoro(phenylsulfonyl)methyl anion
Liu, Jun,Zhang, Laijun,Hu, Jinbo
supporting information; experimental part, p. 5377 - 5380 (2009/06/18)
(Chemical Equation Presented) Pregeneration of fluoro(phenylsulfonyl)methyl anion (PhSO2CHF-) paves the way for the efficient and highly stereoselective monofluoromethylation of (R)-N-tert-butylsulfinyl ketimines. The stereocontrol mode of the present diastereoselective monofluoromethylation of ketimines is different from the previously known nucleophilic fluoroalkylation of (R)-N-tert-butylsulfinyl aldimines, which suggests that a cyclic six-membered transition state (rather than a nonchelation controlled one) is involved in the current ketimine reaction.