109247-96-3Relevant academic research and scientific papers
Antischistosomal properties of aurone derivatives against juvenile and adult worms of Schistosoma mansoni
Pereira, Vinicius R.D.,da Silveira, Lígia S.,Mengarda, Ana C.,Alves Júnior, Ismael J.,da Silva, Ohana Oliveira Zuza,Miguel, Fábio Balbino,Silva, Marcos P.,Almeida, Ayla das C.,Torres, Daniel da Silva,Pinto, Priscila de F.,Coimbra, Elaine S.,de Moraes, Josué,Couri, Mara R.C.,da Silva Filho, Ademar A.
, (2021)
Schistosomiasis is a neglected disease caused by helminth flatworms of the genus Schistosoma, affecting over 240 million people in more than 70 countries. The treatment relies on a single drug, praziquantel, making urgent the discovery of new compounds. A
Scope of mercuric acetate oxidation of chalcones and the antibacterial activity of resulting aurones
Khan,Mueed, M. Asad
, p. 1794 - 1797 (2007/10/03)
Mercuric acetate provides a convenient reagent for oxidative cyclization of 2′-hydroxychalcones resulting in stereospecific formation of Z-aurones. Thirteen aurones have been synthesised with varying substituents for studying the scope of the reaction. The antibacterial activity of these products has been studied against Staphylococcus aureus and Escherichia coli.
An environmentally benign synthesis of aurones and flavones from 2′-acetoxychalcones using n-tetrabutylammonium tribromide
Bose, Gopal,Mondal, Ejabul,Khan, Abu T,Bordoloi, Manob J.
, p. 8907 - 8909 (2007/10/03)
A wide variety of aurones (3a-f) can be prepared exclusively from 2′-acetoxychalcones (1a-f) in high yields in two steps, by bromination using n-tetrabutylammonium tribromide (TBATB) in the presence of CaCO3 in CH2Cl2-MeOH (5:2) at 0-5°C followed by cyclization of the brominated products 2a-f on treating with 0.2 M ethanolic KOH solution at 0-5°C, respectively. In contrast various flavone derivatives 6a-f can be obtained exclusively from compounds 1a-f in fairly good yields, by brominating with the same reagent in CH2Cl2, followed by dehydrobromination and finally cyclization on treating with 0.1 M NaOMe solution.
