109248-36-4Relevant academic research and scientific papers
A sequential one-pot approach to 1,2,4,5-tetrasubstituted-2H-imidazole synthesis from disubstituted alkynes
Boominathan, Siva Senthil Kumar,Chen, Chung-Yu,Huang, Po-Jui,Hou, Ruei-Jhih,Wang, Jeh-Jeng
, p. 6914 - 6918 (2015/09/02)
A sequential one-pot approach to the tetrasubstituted 2H-imidazole scaffolds has been developed from disubstituted alkynes and structurally diverse ketones. The reaction proceeds via a diketo intermediate generated from internal alkynes followed by the addition of ammonium acetate and a suitable ketone, affording a diverse range of 2H-imidazoles. Using air-moisture stable reaction conditions and inexpensive reagents, the transformation demonstrates a broad substrate scope and good functional group compatibility.
Mild Mn(OAc)3-Mediated Aerobic Oxidative Decarboxylative Coupling of Arylboronic Acids and Arylpropiolic Acids: Direct Access to Diaryl 1,2-Diketones
Lv, Wen-Xin,Zeng, Yao-Fu,Zhang, Shang-Shi,Li, Qingjiang,Wang, Honggen
supporting information, p. 2972 - 2975 (2015/06/30)
A simple and efficient method for the synthesis of diaryl 1,2-diketones has been developed. The reaction represents the first example of diaryl 1,2-diketones that are synthesized directly from arylboronic acids and arylpropiolic acids by a radical pathway in moderate to good yields. This reaction proceeds under mild reaction conditions and with good tolerance of a variety of functional groups. Preliminary mechanistic studies were conducted.
Synthesis and antitumor activity of benzils related to combretastatin A-4
Mousset, Celine,Giraud, Anne,Provot, Olivier,Hamze, Abdallah,Bignon, Jerome,Liu, Jian-Miao,Thoret, Sylviane,Dubois, Joelle,Brion, Jean-Daniel,Alami, Mouad
scheme or table, p. 3266 - 3271 (2009/04/05)
A series of benzil derivatives related to combretastatin A-4 (CA-4) have been synthesized by oxidation of diarylalkynes promoted by PdI2 in DMSO. Using this new protocol, 14 benzils were prepared in good to excellent yields and their biological
Microwave-assisted efficient synthesis of 1,2-diaryldiketones: a novel oxidation reaction of diarylalkynes with DMSO promoted by FeBr3
Giraud, Anne,Provot, Olivier,Peyrat, Jean-Fran?ois,Alami, Mouad,Brion, Jean-Daniel
, p. 7667 - 7673 (2007/10/03)
This paper reports the oxidation of functionalized diarylalkynes with DMSO in the presence of the environmentally friendly FeBr3 catalyst. This non-toxic procedure is general and has been applied successfully under microwave irradiation leading rapidly to benzil derivatives in good yields.
