1092491-68-3Relevant academic research and scientific papers
Method for synthesizing fluorescent dye intermediate aldehyde by hydroformylation of 1,3-diene compound
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Paragraph 0053-0057, (2021/08/07)
The invention discloses a method for synthesizing a fluorescent dye intermediate aldehyde by hydroformylation of 1,3-diene compound. The method comprises the following steps: S1, sequentially adding 0.01 mmol (1 mol%) of [Rh(cod)Cl]2, 0.1 mmol of a phosphine ligand(P/Rh=10/1) and 1 mmol of diene into a reaction flask, adding 1 ml of a solvent DMF, putting the reaction flask into a high-pressure reaction kettle, after the reaction is finished, transferring a mixed solution into a 25 mL glass bottle with 200 microliters of n-tridecane as an internal standard by using a rubber head dropper, and detecting; and S2, determining the product yield and the structure through a gas chromatograph and a nuclear magnetic resonance spectrum, wherein the obtained olefin conversion rate is larger than 99%, the aldehyde yield ranges from 61% to 99%, and the regioselectivity of the product aldehyde ranges from 70/30 to 100/0. According to the method disclosed by the invention, the separation and purification steps of aldehyde products are simplified, and the substrate of the dialkene hydroformylation reaction is excellent in universality.
Asymmetric palladium-catalyzed intramolecular α-arylation of aldehydes
Garcia-Fortanet, Jorge,Buchwald, Stephen L.
supporting information; experimental part, p. 8108 - 8111 (2009/04/13)
(Chemical Equation Presented) Phoxy ligand: The first catalytic method for the asymmetric palladium-catalyzed intramolecular α-arylation of α-branched aldehydes was developed (see scheme). This process is distinguished by the high yields and enantioselectivities that can be obtained, making this protocol a useful synthetic tool for further applications.
