1092497-19-2Relevant academic research and scientific papers
"Flash" solvent-free synthesis of triazoles using a supported catalyst
Jlalia, Ibtissem,Meganem, Faouzi,Herscovici, Jean,Girard, Christian
, p. 528 - 539 (2009)
A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst A21?CuI) is presented herein. As it provides the products in high yields and purities within minutes, this me
Automated synthesis of a 96 product-sized library of triazole derivatives using a solid phase supported copper catalyst
Jlalia, Ibtissem,Beauvineau, Claire,Beauviere, Sophie,Oenen, Esra,Aufort, Marie,Beauvineau, Aymeric,Khaba, Eihab,Herscovici, Jean,Meganem, Faouzi,Girard, Christian
experimental part, p. 3087 - 3120 (2010/09/05)
This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.
Copper(I)-doped Wyoming's montmorillonite for the synthesis of disubstituted 1,2,3-triazoles
Jlalia, Ibtissem,Elamari, Hichem,Meganem, Faouzi,Herscovici, Jean,Girard, Christian
scheme or table, p. 6756 - 6758 (2009/04/06)
A new catalytic system based on copper(I)-doped Wyoming's montmorillonite was elaborated. This system was studied and was found to catalyze the formation of 1,4-disubstituted 1,2,3-triazoles when starting from azides and alkynes. It was used for the synth
