1092502-40-3Relevant academic research and scientific papers
Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective α2C adrenergic receptor antagonist
Patel, Snahel D.,Habeski, Wendy M.,Min, Hyunsuk,Zhang, Jiansu,Roof, Robin,Snyder, Bradley,Bora, Gary,Campbell, Brian,Li, Cheryl,Hidayetoglu, Debra,Johnson, Douglas S.,Chaudhry, Archana,Charlton, Maura E.,Kablaoui, Natasha M.
scheme or table, p. 5689 - 5693 (2009/08/07)
The discovery of the CNS-penetrant and selective α2C adrenergic receptor antagonist N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, 13 is described. Structure-activity studies demonstrate the structural requirements for binding affinity, functional activity, and selectivity over other α2-AR subtypes.
