1092521-93-1Relevant articles and documents
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators
Martini, Elisabetta,Norcini, Monica,Ghelardini, Carla,Manetti, Dina,Dei, Silvia,Guandalini, Luca,Melchiorre, Michele,Pagella, Simona,Scapecchi, Serena,Teodori, Elisabetta,Romanelli, Maria Novella
experimental part, p. 10034 - 10042 (2009/04/06)
A series of amides, structurally related to DM232 (unifiram) and DM235 (sunifiram), characterized by a 1,2,3,4-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one, 1,4-diamino-cyclohexane or 1,4-diaminobenzene ring, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, while some cyclohexane derivatives are endowed with amnesia inducing properties.
