109253-05-6

Basic information

• Product Name: N-([1,1′-biphenyl]-2-yl)-4-nitrobenzenesulfonamide
• Synonyms: N-([1,1′-biphenyl]-2-yl)-4-nitrobenzenesulfonamide
• CAS NO: 109253-05-6
• Molecular Weight: 354.386
• Mol File: 109253-05-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-([1,1′-biphenyl]-2-yl)-4-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-([1,1′-biphenyl]-2-yl)-4-nitrobenzenesulfonamide(109253-05-6)
• EPA Substance Registry System: N-([1,1′-biphenyl]-2-yl)-4-nitrobenzenesulfonamide(109253-05-6)

Safety Data

• Hazardous Substances Data: 109253-05-6(Hazardous Substances Data)

Upstream product

• 90-41-5 2-phenylaniline 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 1217169-38-4 C₂₂H₂₀N₂O₆S 

Relevant articles and documents

Ligand-Enabled meta-Selective C-H Arylation of Nosyl-Protected Phenethylamines, Benzylamines, and 2-Aryl Anilines

A Pd-catalyzed, meta-selective C-H arylation of nosyl-protected phenethylamines and benzylamines is disclosed using a combination of norbornene and pyridine-based ligands. Subjecting nosyl protected 2-aryl anilines to this protocol led to meta-C - H arylation at the remote aryl ring. A diverse range of aryl iodides are tolerated in this reaction, along with select heteroaryl iodides. Select aryl bromides bearing ortho-coordinating groups can also be utilized as effective coupling partners in this reaction. The use of pyridine ligands has allowed the palladium loading to be reduced to 2.5 mol %. Furthermore, a catalytic amount of 2-norbomene (20 mol %) to mediate this meta-C - H activation process is demonstrated for the first time. Utilization of a common protecting group as the directing group for meta-C-H activation of amines is an important feature of this reaction in terms of practical applications.

Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants

New structural classes of KV1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte pr