109253-84-1Relevant academic research and scientific papers
An efficient synthesis of polysubstituted naphthalene derivatives by gold-catalyzed cyclization of 1-arylalka-2,3-dienyl acetates
Kong, Wangqing,Fu, Chunling,Ma, Shengming
supporting information; experimental part, p. 6545 - 6555 (2011/02/24)
An efficient synthetic strategy to generate differently polysubstituted naphthalenes and iodonaphthalenes through a gold-catalyzed cyclization reaction of 1-arylalka-2,3-dienyl acetates was described. Due to the substituent loading capability of both the
New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase - Discovery of a new polyhydroxylated antiviral agent
Maurin, Cedric,Lion, Cedric,Bailly, Fabrice,Touati, Nadia,Vezin, Herve,Mbemba, Gladys,Mouscadet, Jean Franois,Debyser, Zeger,Witvrouw, Myriam,Cotelle, Philippe
experimental part, p. 5194 - 5201 (2010/09/05)
A series of 13 hydroxylated 2-arylnaphthalenes have been synthesized and evaluated as HIV-1 integrase inhibitors. 7-(3,4,5-Trihydroxyphenyl)naphthalene- 1,2,3-triol 1c revealed chemical instability upon storage, leading to the isolation of a dimer 5c which was also tested. In the 2-arylnaphthalene series, all compounds were active against HIV-1 IN with IC50's within the 1-10 μM range, except for 1c and 5c which displayed submicromolar activity. Antiviral activity against HIV-1 replication was measured on 1b-c and 5c. Amongst the tested molecules, only 5c was found to present antiviral properties with a low cytotoxicity on two different cell lines.
Heteroatom directed lithiation reaction in organic synthesis : Synthesis of styrylphthalans and functionalised naphthalenes
Mali,Jagtap,Borse
, p. 116 - 120 (2007/10/03)
Lithiation of N,N-dimethylbenzylamines (la-c) using n-butyllithium followed by treatment with cinnamaldehyde give amino alcohols (2a-c), which on reaction with ethyl chloroformate followed by heating yield phthalans (4a-c). Aminoalcohols (2a-c) on sequential reactions with ethyl chloroformate and potassium cyanide afford the naphthalenes (5a-c and 6a-b). The quaternary salts 8a-c, obtained from 2a-c, also react with potassium cyanide in N,N-dimethylformamide to give the substituted naphthalenes (5a-c and 6a-b).
