1092544-69-8Relevant articles and documents
The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor
Naidu, B. Narasimhulu,Walker, Michael A.,Sorenson, Margaret E.,Ueda, Yasutsugu,Matiskella, John D.,Connolly, Timothy P.,Dicker, Ira B.,Lin, Zeyu,Bollini, Sagarika,Terry, Brian J.,Higley, Helen,Zheng, Ming,Parker, Dawn D.,Wu, Dedong,Adams, Stephen,Krystal, Mark R.,Meanwell, Nicholas A.
, p. 2124 - 2130 (2018)
BMS-707035 is an HIV-1 integrase strand transfer inhibitor (INSTI) discovered by systematic optimization of N-methylpyrimidinone carboxamides guided by structure-activity relationships (SARs) and the single crystal X-ray structure of compound 10. It was r
HIV Integrase Inhibitors
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, (2009/01/20)
The invention encompasses a series pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pha