1092544-74-5

Basic information

• Product Name: N-(4-fluoro-2-(1-methyl-1H-1,2,4-triazol-5-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide
• CAS NO: 1092544-74-5
• Molecular Weight: 428.423
• Mol File: 1092544-74-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-fluoro-2-(1-methyl-1H-1,2,4-triazol-5-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluoro-2-(1-methyl-1H-1,2,4-triazol-5-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide(1092544-74-5)
• EPA Substance Registry System: N-(4-fluoro-2-(1-methyl-1H-1,2,4-triazol-5-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide(1092544-74-5)

Safety Data

• Hazardous Substances Data: 1092544-74-5(Hazardous Substances Data)

Upstream product

• 1092544-68-7 ethyl 5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxylate 
• 1092544-67-6 ethyl 5-(2-ethoxy-2-oxoethyl)-2-methyl-3-(tetrahydrofuran-3-yl)-2,5-dihydro-1,2,4-oxadiazole-5-carboxylate 
• 14631-44-8 3-cyanotetrahydrofuran 

Relevant articles and documents

Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors

Integration of viral DNA into the host cell genome is an obligatory process for successful replication of HIV-1. Integrase catalyzes the insertion of viral DNA into the target DNA and is a validated target for drug discovery. Herein, we report the synthesis, antiviral activity and pharmacokinetic profiles of several C2-carbon-linked heterocyclic pyrimidinone-4-carboxamides that inhibit the strand transfer step of the integration process.