1092544-75-6Relevant academic research and scientific papers
Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors
Naidu, B. Narasimhulu,Sorenson, Margaret E.,Patel, Manoj,Ueda, Yasutsugu,Banville, Jacques,Beaulieu, Francis,Bollini, Sagarika,Dicker, Ira B.,Higley, Helen,Lin, Zeyu,Pajor, Lori,Parker, Dawn D.,Terry, Brian J.,Zheng, Ming,Martel, Alain,Meanwell, Nicholas A.,Krystal, Mark,Walker, Michael A.
, p. 717 - 720 (2015)
Integration of viral DNA into the host cell genome is an obligatory process for successful replication of HIV-1. Integrase catalyzes the insertion of viral DNA into the target DNA and is a validated target for drug discovery. Herein, we report the synthesis, antiviral activity and pharmacokinetic profiles of several C2-carbon-linked heterocyclic pyrimidinone-4-carboxamides that inhibit the strand transfer step of the integration process.
HIV Integrase Inhibitors
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Page/Page column 12, (2009/01/20)
The invention encompasses a series pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pha
