1092547-45-9Relevant academic research and scientific papers
A novel diastereoselective 1,3-dipolar cycloaddition approach to cis-fused bispyrrolidines
Poornachandran, Mahalingam,Raghunathan, Raghavachary
experimental part, p. 2177 - 2183 (2009/04/11)
The intramolecular cycloaddition reactions of non-stabilized azomethine ylides generated by the condensation of N-aryl glycines and an enantiopure N-allyl-tethered alkenyl aldehyde derived from (S)-phenyl alanine were investigated. The stereoselective reactions led to the formation of novel cis-fused enantiomerically pure octahydropyrrolo[3,4-b]pyrroles, and the strategy was expanded to the synthesis of enantiopure novel heterotricyclic skeletons, perhydrothiazolo[3′,4′-2,3]pyrrolo[4,5-c]pyrroles.
