1092578-27-2Relevant articles and documents
Switch off/switch on regulation of drug cytotoxicity by conjugation to a cell targeting peptide
Gilad, Yossi,Firer, Michael A.,Rozovsky, Alex,Ragozin, Elena,Redko, Boris,Albeck, Amnon,Gellerman, Gary
, p. 139 - 146 (2014)
Bi-nuclear amino acid platforms loaded with various drugs for conjugation to a peptide carrier were synthesized using simple and convenient orthogonally protective solid-phase organic synthesis (SPOS). Each arm of the platform carries a different anticancer agent linked through the same or different functional group, providing discrete chemo-and bio-release profiles for each drug, and also enabling switch off/switch regulation of drug cytotoxicity by conjugation to the platform and to a cell targeting peptide. The versatility of this approach enables efficient production of drug-loaded platforms and determination of favorable drug combinations/modes of linkage for subsequent conjugation to a carrier moiety for targeted cancer cell therapy. The results presented here potentiate the application of amino acid platforms for targeted drug delivery (TDD).