109258-81-3Relevant academic research and scientific papers
Synthesis and characterization of novel bio-based benzoxazines from gallic acid with latent catalytic characteristics
Arslan, Mustafa
, p. 9 - 16 (2019)
A novel bio-based main chain benzoxazine with two oxazine rings and one phenolic hydroxyl group in the same aromatic ring was synthesized and characterized. The method includes the synthesis of polymeric benzoxazine precursors from simple chemicals such a
Design and synthesis of gallocyanine inhibitors of DKK1/LRP6 interactions for treatment of Alzheimer's disease
Thysiadis, Savvas,Katsamakas, Sotirios,Mpousis, Spyros,Avramidis, Nicolaos,Efthimiopoulos, Spiros,Sarli, Vasiliki
, p. 230 - 244 (2018)
Based on NCI8642, a series of gallocyanine derivatives was synthesized with modifications of the substituent groups in position 1, 2 and 4 of the phenoxazinone scaffold. The effectiveness of gallocyanines to inhibit DKK1/LRP6 interactions and Tau phosphorylation induced by prostaglandin J2 and DKK1 was elucidated by both experimental data and molecular docking simulations. Bis-alkylated with flexible alkyl ester groups on C1 and bis-benzyl gallocyanines provided the most active inhibitors, while amino derivatives on C2 of NCI8642 that have alkoxy or benzyloxy substituents on C4, were less active. Furthermore, it is shown that treating of SHSY5Y cells with NCI8642 derivatives activates Wnt signaling and increases the levels of pGSK3β kinase and β-catenin.
Novel Enzymatic De-esterification Studies on Substituted Polyacetoxybenzamides
Parmar, Virinder S.,Kumar, Ajay,Prasad, Ashok K.,Kumar, Rajesh,Bisht, Kirpal S.,Poonam,Jain, Subhash C.,Olsen, Carl E.
, p. 810 - 822 (2007/10/03)
The regioselective capabilities of porcine pancreatic lipase in tetrahydrofuran and Candida rugosa lipase in diisopropyl ether have been investigated for selective deacetylation of peracetates of primary, secondary and tertiary amides of 2-hydroxy-, 2,4-dihydroxy-, 2,5-dihydroxy-, 3,5-dihydroxy- and 3,4,5-trihydroxybenzoic acids. The lipases exhibit random selectivity for the deacetylation of ortho-, meta- and para-acetoxy functions of di/triacetoxybenzamides leading to the formation of the corresponding partially and/or completely deacetylated benzamides. The amide group of all substrates under investigation remains inert to enzymatic hydrolysis. The results of deesterification are in good agreement with our earlier proposed mechanism of action of porcine pancreatic lipase on diaryl or aryl alkyl ketones in organic solvents.
