1092689-33-2

Basic information

• Product Name: (4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine HCL
• Synonyms: (4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine HCL;Tetrazine-Amine;Tetrazine – Amine, HCl salt
• CAS NO: 1092689-33-2
• Molecular Formula: C₉H₉N₅
• Molecular Weight: 223.6622
• Mol File: 1092689-33-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 403.4±47.0 °C(Predicted)
• Appearance: /
• Density: 1.268±0.06 g/cm3(Predicted)
• PKA: 8.31±0.10(Predicted)
• CAS DataBase Reference: (4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine HCL(1092689-33-2)
• EPA Substance Registry System: (4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine HCL(1092689-33-2)

Safety Data

• Hazardous Substances Data: 1092689-33-2(Hazardous Substances Data)

Usage

General Description

The chemical compound (4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine HCL is a crystalline solid that is commonly used in research laboratories as a reagent and building block for the synthesis of various organic compounds. It is also known for its potential use in medical and pharmaceutical applications due to its unique structure and properties. The compound is typically handled with care and in controlled environments, as it may be hazardous if not properly handled. Its precise molecular structure and properties make it an important tool for chemical and biological research, as well as potential applications in drug development and other areas of science and technology.

Upstream product

• 3473-63-0 formamidine acetic acid 
• 15996-76-6 4-cyanobenzylamine hydrochloride 
• 66389-80-8 tert-butyl N-[(4-cyanophenyl)methyl]carbamate 
• 1380500-93-5 tert-butyl N-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]carbamate 

Downstream Products

• 1225194-70-6 N-(4-(1,2,4,5-tetrazin-3-yl)benzyl)-3-(5,5-difluoro-7,9-dimethyl-5H-4λ⁴,5λ⁴-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinin-3-yl)propenamide 
• 1225146-53-1 5-(4-(1,2,4,5-tetrazin-3-yl)benzylamino)-5-oxopentanoic acid 
• 1286255-39-7 AZD₂₂₈₁-Tz 
• 1440324-47-9 3-(4-Isothiocyanatomethyl-phenyl)-[1,2,4,5]tetrazine 

Relevant articles and documents

In Vivo Targeting through Click Chemistry

Targeting small molecules to diseased tissues as therapy or diagnosis is a significant challenge in drug delivery. Drug-eluting devices implanted during invasive surgery allow the controlled presentation of drugs at the disease site, but cannot be modified once the surgery is complete. We demonstrate that bioorthogonal click chemistry can be used to target circulating small molecules to hydrogels resident intramuscularly in diseased tissues. We also demonstrate that small molecules can be repeatedly targeted to the diseased area over the course of at least one month. Finally, two bioorthogonal reactions were used to segregate two small molecules injected as a mixture to two separate locations in a mouse disease model. These results demonstrate that click chemistry can be used for pharmacological drug delivery, and this concept is expected to have applications in refilling drug depots in cancer therapy, wound healing, and drug-eluting vascular grafts and stents.

Selective CRAF Inhibition Elicits Transactivation

Discovering molecules that regulate closely related protein isoforms is challenging, and in many cases the consequences of isoform-specific pharmacological regulation remains unknown. RAF isoforms are commonly mutated oncogenes that serve as effector kinases in MAP kinase signaling. BRAF/CRAF heterodimers are believed to be the primary RAF signaling species, and many RAF inhibitors lead to a "paradoxical activation"of RAF kinase activity through transactivation of the CRAF protomer; this leads to resistance mechanisms and secondary tumors. It has been hypothesized that CRAF-selective inhibition might bypass paradoxical activation, but no CRAF-selective inhibitor has been reported and the consequences of pharmacologically inhibiting CRAF have remained unknown. Here, we use bio-orthogonal ligand tethering (BOLT) to selectively target inhibitors to CRAF. Our results suggest that selective CRAF inhibition promotes paradoxical activation and exemplify how BOLT may be used to triage potential targets for drug discovery before any target-selective small molecules are known.

COMPOSITIONS AND METHODS FOR DELIVERING A SUBSTANCE TO A BIOLOGICAL TARGET

The present application provides compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reaction for rapid and specific covalent delivery of a payload to a ligand bound to a biological target.