1092694-41-1Relevant articles and documents
Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists
Lange, Jos H.M.,Attali, Amos,Van Der Neut, Martina A.W.,Wals, Henri C.,Mulder, Arie,Zilaout, Hicham,Duursma, Ate,Van Aken, Hans H.M.,Van Vliet, Bernard J.
, p. 4992 - 4998 (2010)
The synthesis and SAR of 3-alkyl-4-aryl-4,5-dihydropyrazole-1-carboxamides 1-23 and 1-alkyl-5-aryl-4,5-dihydropyrazole-3-carboxamides 24-27 as two novel cannabinoid CB1 receptor agonist classes were described. The target compounds elicited high
4,5 Dihydro-(1H)-Pyrazole Derivatives as Cannabinoid CB1 Receptor Modulators
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Page/Page column 10, (2009/01/24)
The invention is directed to 4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB1 receptor modulators, to pharmaceutical compositions comprising these compounds, to methods for their syntheses, to methods for preparing novel intermediates useful for their syntheses, and to methods for preparing compositions. The invention also relates to the uses of compounds and compositions administered to patients to achieve a therapeutic effect in multiple sclerosis, traumatic brain injury, pain including chronic pain, neuropathic pain, acute pain and inflammatory pain, osteoporosis, appetite disorders, epilepsy, Alzheimer's disease, Tourette's syndrome, cerebral ischaemia, emesis, nausea, and gastrointestinal disorders. Compounds of the present disclosure are directed to formula (I): wherein the substituents have the definitions given in the specification.
