109274-99-9 Usage
Uses
Used in Pharmaceutical Industry:
Furo[2,3-b]pyridine-3-carboxaldehyde (9CI) is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable building block for the development of new drugs.
Used in Agrochemical Industry:
Furo[2,3-b]pyridine-3-carboxaldehyde (9CI) is utilized as a precursor in the production of agrochemicals, contributing to the development of effective and innovative solutions for agriculture.
Used in Organic Synthesis:
Furo[2,3-b]pyridine-3-carboxaldehyde (9CI) is employed as a key component in the synthesis of diverse heterocyclic compounds, expanding the scope of organic chemistry and enabling the creation of novel materials.
Used in Chemical Research:
Furo[2,3-b]pyridine-3-carboxaldehyde (9CI) serves as a valuable research tool in the field of chemical research, providing insights into the properties and reactions of heterocyclic compounds and contributing to the advancement of scientific knowledge.
It is important to handle Furo[2,3-b]pyridine-3-carboxaldehyde (9CI) with care due to its potential hazards if not used properly.
Check Digit Verification of cas no
The CAS Registry Mumber 109274-99-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,2,7 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 109274-99:
(8*1)+(7*0)+(6*9)+(5*2)+(4*7)+(3*4)+(2*9)+(1*9)=139
139 % 10 = 9
So 109274-99-9 is a valid CAS Registry Number.
109274-99-9Relevant academic research and scientific papers
Furopyridines. VI. Preparation and Reactions of 2- and 3- Substituted Furopyridines
Morita, Hiroyuki,Shiotani,Shunsaku
, p. 1465 - 1469 (2007/10/02)
This paper describes the synthesis and chemical properties of some 2- and 3-substituted furopyridines.Reaction of ethyl 2-chloronicotinate 1 with sodium ethoxycarbonylmethoxide or 1-ethoxycarbonyl-1-ethoxide gave β-keto ester 2 or ketone 5, respectively.Ketonic hydrolysis of 2 afforded ketone 3, from which furopyridine 4 was obtained by the method Sliwa.While, 2-methyl derivative 7 was prepared from 5 by reduction, O-acetylation and the subsequent pyrolysis.Reaction of ketone 3 with methyllithium gave tertiary alcohol 8 which was O-acetylated and pyrolyzed to give 3-methyl derivative 9.Formylation of 4, via lithio intermediate, with DMF yielded 2-formyl derivative 10, from which 7, was obtained by Wolff-Kishner reduction.Dehydration of the oxime 11 of 10 gave 2-cyano derivative 12, which was hydrolyzed to give 2-carboxylic acid 13.Reaction of 3-bromo compound 14 with copper(I)cyanide gave 3-cyano derivative 15.Alkaline hydrolysis of 15 afforded compound 16 and 17, while acidic hydrolysis gave carboxamide 18.Reduction of 15 with DIBAL-H afforded 3-formyl derivative 19.Wolff-Kishner reduction of 19 gave no reduction product 9 but hydrazone 20.Reduction of tosylhydrazone 21 with sodium borohydride in methanol afforded 3-methoxymethylfuropyridine 22.
