1092829-93-0Relevant academic research and scientific papers
Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors
Lahue, Brian R.,Ma, Yao,Shipps Jr., Gerald W.,Seghezzi, Wolfgang,Herbst, Ronald
scheme or table, p. 3405 - 3409 (2010/02/28)
Substituted benzimidazoles were profiled as inhibitors of kinesin spindle protein (KSP), an increasingly important target for the development of anticancer drugs. This series demonstrated the monoastral phenotypic response and was found to be active in bo
COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY
-
Page/Page column 131, (2009/01/24)
The present invention provides compounds of Formula (I); wherein R, R1, R2, R3, and R4 are as defined herein. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disor
