1092941-06-4

Basic information

• Product Name: 2-(4-n-dodecyl-1,2,3-triazol-1-yl)-5'-O-[N-(2-hydroxybenzoyl)sulfamoyl]adenosine triethylammonium
• Synonyms: 2-(4-n-dodecyl-1,2,3-triazol-1-yl)-5'-O-[N-(2-hydroxybenzoyl)sulfamoyl]adenosine triethylammonium
• CAS NO: 1092941-06-4
• Molecular Weight: 802.996
• Mol File: 1092941-06-4.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-n-dodecyl-1,2,3-triazol-1-yl)-5'-O-[N-(2-hydroxybenzoyl)sulfamoyl]adenosine triethylammonium(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-n-dodecyl-1,2,3-triazol-1-yl)-5'-O-[N-(2-hydroxybenzoyl)sulfamoyl]adenosine triethylammonium(1092941-06-4)
• EPA Substance Registry System: 2-(4-n-dodecyl-1,2,3-triazol-1-yl)-5'-O-[N-(2-hydroxybenzoyl)sulfamoyl]adenosine triethylammonium(1092941-06-4)

Safety Data

• Hazardous Substances Data: 1092941-06-4(Hazardous Substances Data)

Upstream product

• 765-10-6 1-tetradecyne 
• 1092940-84-5 2-azido-5'-O-[N-(2-hydroxybenzoyl)sulfamoyl]adenosine triethylammonium 

Relevant articles and documents

Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5′-O-[N-(salicyl)sulfamoyl]adenosine: Antibacterial nucleosides effective against Mycobacterium tuberculosis

The synthesis, biochemical, and biological evaluation of a systematic series of 2-triazole derivatives of 5′-O-[N-(salicyl)sulfamoyl]adenosine (Sal-AMS) are described as inhibitors of aryl acid adenylating enzymes (AAAE) involved in siderophore biosynthesis by Mycobacterium tuberculosis. Structure-activity relationships revealed a remarkable ability to tolerate a wide range of substituents at the 4-position of the triazole moiety, and a majority of the compounds possessed subnanomolar apparent inhibition constants. However, the in vitro potency did not always translate into whole cell biological activity against M. tuberculosis, suggesting that intrinsic resistance plays an important role in the observed activities. Additionally, the well-known valence tautomerism between 2-azidopurines and their fused tetrazole counterparts led to an unexpected facile acylation of the purine N-6 amino group.