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1092942-82-9

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1092942-82-9 Usage

Description

Imatinib-d8, also known as Labeled Imatinib, is a deuterated tyrosine kinase inhibitor. It is a stable isotope-labeled analog of Imatinib, which is a small molecule drug used to treat various cancers. Imatinib-d8 is characterized by the incorporation of deuterium atoms into its molecular structure, which provides enhanced stability and sensitivity in analytical techniques.

Uses

Used in Pharmaceutical Analysis:
Imatinib-d8 is used as an internal standard for the quantification of Imatinib by gas chromatography (GC) or liquid chromatography (LC) mass spectrometry. Its stable isotopic composition allows for accurate and precise measurement of Imatinib levels in biological samples, ensuring reliable results in pharmacokinetic and pharmacodynamic studies.
Used in COVID-19 Research:
Imatinib-d8 is a COVID-19-related research product, utilized in the investigation of the SARS-CoV-2 virus and its impact on human health. As a tyrosine kinase inhibitor, it may have potential applications in modulating the host's immune response to the virus, as well as interfering with viral replication and entry into host cells. Further research is needed to explore its efficacy and safety in the context of COVID-19 treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 1092942-82-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,2,9,4 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1092942-82:
(9*1)+(8*0)+(7*9)+(6*2)+(5*9)+(4*4)+(3*2)+(2*8)+(1*2)=169
169 % 10 = 9
So 1092942-82-9 is a valid CAS Registry Number.

1092942-82-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-[(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)methyl]benzamide

1.2 Other means of identification

Product number -
Other names STI 571

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1092942-82-9 SDS

1092942-82-9Downstream Products

1092942-82-9Relevant articles and documents

METHODS AND INTERMEDIATES FOR THE PREPARATION OF OPTIONALLY RADIO-LABELED IMATINIB

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Page/Page column 22-23, (2008/06/13)

The invention relates to new processes for the manufacture of N-{5-[4-(4-methyl-piperazino- methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine of formula (I), new processes for the manufacture of metabolites of N-{5-[4-(4-methyl-piperazino-methyl)- benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine observed after administration of the compound to warm-blooded animals as well as to intermediates used in said processes. New starting materials as well as processes for the preparation thereof are likewise the subject of this invention. The processes described herein are especially suitable to furnish said compounds having isotopic labeling. The such obtained labeled compounds are in particular suitable to track and to investigate into the metabolism of N-{5-[4-(4-methyl- piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and its pharmaceutically acceptable salts in clinical and pre-clinical studies.

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