1092953-85-9Relevant academic research and scientific papers
N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl) heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists
Newman, Amy Hauck,Grundt, Peter,Cyriac, George,Deschamps, Jeffrey R.,Taylor, Michelle,Kumar, Rakesh,Ho, David,Luedtke, Robert R.
experimental part, p. 2559 - 2570 (2010/03/01)
In the present report, the D3 receptor pharmacophore is modified in the 2,3-diCl- and 2-OCH3-phenyl-piperazine class of compounds with the goal to improve D3 receptor affinity and selectivity. This extension of structure-activity relationships
4-PHENYLPIPERAZINE DERIVATIVES WITH FUNCTIONALIZED LINKERS AS DOPAMINE D3 RECEPTOR SELECTIVE LIGANDS AND METHODS OF USE
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Page/Page column 3/3, (2009/01/24)
Dopamine D3 receptor antagonists and partial agonists are known to modulate the reinforcing and drug-seeking effects induced by cocaine and other abused substances. By introducing functionality into the butylamide linking chain of the 4-phenylp
