109296-17-5

Upstream product

• 91097-63-1 ((3Z)-7-methoxycarbonyl-3-heptenyl)-triphenylphosphonium iodide 

Downstream Products

• 110822-71-4 Benzoic acid (4Z,7Z)-(S)-2-hydroxy-11-methoxycarbonyl-undeca-4,7-dienyl ester 
• 90080-07-2 8(R),9(S)-epoxyeicosatrienoic acid methyl ester 
• 90080-08-3 11(S),12(R)-epoxyeicosatrienoic acid methyl ester 
• 100428-45-3 (R)-methyl (5Z,8Z,10Z,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoate 
• 131938-77-7 Benzoic acid (2E,4Z,7Z)-(R)-1-((Z)-(R)-1-hydroxy-oct-2-enyl)-11-methoxycarbonyl-undeca-2,4,7-trienyl ester 
• 131938-78-8 Benzoic acid (3E,5Z,8Z)-(1R,2R)-1-((Z)-hept-1-enyl)-2-hydroxy-12-methoxycarbonyl-dodeca-3,5,8-trienyl ester 
• 131138-12-0 (Z,Z,E,E,R)methyl 14-benzoyloxy 5,8,10,12 eicosatetraenoate 
• 119119-46-9 (5Z,8Z)-9-[(2R,3R,4R)-3,4-Bis-(3,4-dimethoxy-benzyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-nona-5,8-dienoic acid methyl ester 
• 160017-28-7 (5Z,8Z)-(S)-10-[(4R,5R)-2,2-Dimethyl-5-((Z)-oct-2-enyl)-[1,3]dioxolan-4-yl]-10-(4-methoxy-benzyloxy)-deca-5,8-dienoic acid methyl ester 
• 160031-42-5 (5Z,8Z,14Z)-(11S,12R)-12-Hydroxy-11-(4-methoxy-benzyloxy)-icosa-5,8,14-trienoic acid methyl ester 
• 160031-41-4 (5Z,8Z,14Z)-(11R,12R)-12-Hydroxy-11-(4-methoxy-benzyloxy)-icosa-5,8,14-trienoic acid methyl ester 
• 54397-83-0 12-hydroxyeicosatetraenoic acid 
• 82337-46-0 (R)-12-HETE 
• 1443619-83-7 C₂₄H₂₉F₃O₄ 

Relevant academic research and scientific papers

Total synthesis of 12(R)-HETE, 12(S)-HETE, 2H2-12(R)-HETE and LTB4 from racemic glycidol via hydrolytic kinetic resolution

The total synthesis of 12(R)-HETE, 12(S)-HETE (Samuelsson's HETE), [14,15-2H2]-12(R)-HETE and Leukotriene B4 from racemic glycidol is described. The key steps are the hydrolytic kinetic resolution of racemic TES-glycidol with salen-Co catalyst and the selective oxidation of primary silyl ethers, in the presence of secondary ones, under Swern conditions to give a short entry to both enantiomers of 12-HETE and LTB4.