109300-07-4Relevant academic research and scientific papers
A Facile Synthesis and Solvolysis of 4-methylene-2-phenyl-2-oxazolin-5-one
Tripathy, Pradeep K.,Roy, Jalpana,Mukerjee, Arya K.
, p. 1275 - 1276 (2007/10/02)
2-Phenyl-2-oxazolin-5-one, generated in benzene by cyclising hippuric acid (1) with ethyl chloroformate in the presence of triethylamine, affords 4-bis(methylthio)methylene-2-phenyl-2-oxazolin-5-one (2), on reaction with carbon disulphide and subsequent methylation with methyl iodide in the presence of triethylamine.All these reactions occur in one-pot.Hydrolysis and alcoholysis of 2 give the acid (3a) and the esters (3b,c), respectively.
