109304-04-3

Basic information

• Product Name: 2-AMinopurine -9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside
• Synonyms: 2-AMinopurine -9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside;2-AMino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine;9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-2-amine
• CAS NO: 109304-04-3
• Molecular Formula: C10H12FN5O3
• Molecular Weight: 269.24
• Mol File: 109304-04-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMinopurine -9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMinopurine -9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside(109304-04-3)
• EPA Substance Registry System: 2-AMinopurine -9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside(109304-04-3)

Safety Data

• Hazardous Substances Data: 109304-04-3(Hazardous Substances Data)

Usage

General Description

2-Aminopurine-9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside is a chemical compound that consists of a modified nucleoside with a fluoro-substituted deoxyribose sugar and a 2-aminopurine base. It is often used in biochemical research as a fluorescent analog of adenine in DNA and RNA, allowing for the study of nucleic acid structure and interactions. 2-AMinopurine -9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside has also been studied for its potential applications in cancer treatment and antiviral therapies, as well as in the development of new nucleoside analog drugs. Its unique structure makes it a valuable tool in molecular biology and pharmaceutical research.

Upstream product

• 452-06-2 9H-purin-2-amine 
• 850883-62-4 2-deoxy-2-fluoro-α-D-arabinofuranose 1-phosphate 
• 56287-17-3 2'-deoxy-2'-fluorouridine 

Relevant articles and documents

Purine 2'-deoxy-2'-fluororibosides as antiinfluenza virus agents

Twenty purine 2'-deoxy-2'-fluororibosides were synthesized by enzymic pentosyl transfer from 2'-deoxy-2'-fluorouridine. Each nucleoside analogue was assayed for cytotoxicity in uninfected Madin-Darby canine kidney cells and for their ability to suppress influenza A virus infections in these cells. The most potent antivirial activity was observed with analogues having an amino group in the 2-position of the purine moiety. All 2-unsubstituted analogues were less potent than their 2-amino counterparts. Furthermore, 2- methyl, 2-methoxy, or 2-fluoro substitution obliterated antivirial activity. The most cytotoxic member of the series was the 2-fluoro-6-amino analogue (IC50 = 120 μM). 2'-Deoxy-2'-fluoroguanosine and those congeners readily converted to it by adenosine deaminase showed the most potent antivirial activity (IC50 = 15-23 μM). Little cytotoxicity was observed with this subgroup of analogues which renders them worthy of further investigation as potential antiinfluenza agents.

Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides

A method for treating two specific protozoal infections, Trichomonas vaginalis and Giardia lamblia, comprising the administration to a mammal in need thereof one of the following purine nucleosides: 2,6-diamino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine 2-amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine 2-amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-6-methoxy-9H-purine.