109305-98-8

Basic information

• Product Name: 2-BROMO-4,5-DIMETHOXY-BENZONITRILE
• Synonyms: 2-BROMO-4,5-DIMETHOXY-BENZONITRILE;AKOS B005114
• CAS NO: 109305-98-8
• Molecular Formula: C₉H₈BrNO₂
• Molecular Weight: 242.07
• Mol File: 109305-98-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 118-119 °C
• Boiling Point: 325.1°C at 760 mmHg
• Flash Point: 150.4°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 0.000235mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMO-4,5-DIMETHOXY-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4,5-DIMETHOXY-BENZONITRILE(109305-98-8)
• EPA Substance Registry System: 2-BROMO-4,5-DIMETHOXY-BENZONITRILE(109305-98-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• RIDADR: UN3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 109305-98-8(Hazardous Substances Data)

Usage

General Description

2-Bromo-4,5-dimethoxy-benzonitrile is a chemical compound with the molecular formula C9H8BrNO2. It is a white solid with a molecular weight of 248.07 g/mol. 2-BROMO-4,5-DIMETHOXY-BENZONITRILE is used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and pharmaceuticals. It is also used as a reagent in organic synthesis reactions, particularly in the production of aromatic compounds. Additionally, it has potential applications in the fields of agrochemicals and materials science. Its unique chemical properties make it a valuable building block for the creation of diverse molecules with beneficial applications in various industries.

InChI:InChI=1/C9H8BrNO2/c1-12-8-3-6(5-11)7(10)4-9(8)13-2/h3-4H,1-2H3

Upstream product

• 2024-83-1 veratronitrile 
• 1428637-19-7 C₁₀H₁₂BrNO₃ 
• 37895-73-1 1,2-dibromo-4,5-dimethoxybenzene 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 198204-67-0 2-bromo-4,5-dimethoxybenzaldehyde oxime 
• 108-24-7 acetic anhydride 
• 53207-00-4 1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene 
• 52806-46-9 1-bromo-4,5-dimethoxy-2-methylbenzene 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 82463-75-0 2-bromo-4,5-dimethoxy-benzamide 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 

Downstream Products

• 198204-16-9 methyl 3-amino-5,6-dimethoxy[1]benzothiophene-2-carboxylate 
• 1251924-24-9 2-bromo-4,5-dimethoxybenzylamine hydrochloride 
• 1293324-06-7 (2-bromo-4,5-dimethoxybenzyl)carbamic acid tert-butyl ester 
• 1293324-13-6 (2-bromo-4,5-dimethoxybenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester 

Relevant articles and documents

Oxidative degradation of arylfuro-1,2-oxazoles to arylnitriles by potassium permanganate

Arylfuroisoxazolines are oxidatively degraded to arylnitriles by treatment with a mixture of potassium permanganate and sodium acetate in dry dioxane.

HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles

We report an efficient HCl·DMPU assisted one-pot conversion of aldehydes into nitriles. The use of HCl·DMPU as both an acidic source as well as a non-nucleophilic base constitutes an environmentally mild alternative for the preparation of nitriles. Our protocol proceeds smoothly without the use of toxic reagents and metal catalysts. Diverse functionalized aromatic, aliphatic and allylic aldehydes incorporating various functional groups were successfully converted to nitriles in excellent to quantitative yields. This protocol is characterized by a broad substrate scope, mild reaction conditions, and high scalability. This journal is

Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO

A simple, mild, and practical process for direct conversion of aldehydes to nitriles was developed feathering a wide substrate scope and great functional group tolerability (52 examples, over 90% yield in most cases) using inorganic reagents (NH2OH/Na2CO3/SO2F2) in DMSO. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable nitriles in a pot, atom, and step-economical manner without transition metals. This protocol will serve as a robust tool for the installation of cyano-moieties to complicated molecules.