1093066-72-8

Basic information

• Product Name: [1-(tert-butyl-dimethyl-silanyl)-5-fluoro-1H-indol-4-yl]boronic acid
• Synonyms: [1-(tert-butyl-dimethyl-silanyl)-5-fluoro-1H-indol-4-yl]boronic acid;1-(tert-butyldiMethylsilyl)-5-fluoro-1H-indol-4-ylboronic acid
• CAS NO: 1093066-72-8
• Molecular Formula: C14H21BFNO2Si
• Molecular Weight: 293.2169432
• EINECS: 604-604-1
• Mol File: 1093066-72-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: [1-(tert-butyl-dimethyl-silanyl)-5-fluoro-1H-indol-4-yl]boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(tert-butyl-dimethyl-silanyl)-5-fluoro-1H-indol-4-yl]boronic acid(1093066-72-8)
• EPA Substance Registry System: [1-(tert-butyl-dimethyl-silanyl)-5-fluoro-1H-indol-4-yl]boronic acid(1093066-72-8)

Safety Data

• Hazardous Substances Data: 1093066-72-8(Hazardous Substances Data)

Usage

General Description

[1-(tert-butyl-dimethyl-silanyl)-5-fluoro-1H-indol-4-yl]boronic acid is a chemical compound with potential biological and pharmaceutical applications. It is a boronic acid derivative containing a fluorine-substituted indole ring. The presence of boronic acid makes it a valuable tool in organic synthesis and as a building block in the preparation of pharmaceutical compounds. The tert-butyl-dimethyl-silanyl group provides stability and protection for the indole ring, making this compound useful in the synthesis of complex molecules and drug development. Its fluorine substitution may also confer useful properties in pharmaceutical applications. Overall, [1-(tert-butyl-dimethyl-silanyl)-5-fluoro-1H-indol-4-yl]boronic acid is a versatile compound with potential utility in the development of new drugs and chemical processes.

InChI:InChI=1S/C14H21BFNO2Si/c1-14(2,3)20(4,5)17-9-8-10-12(17)7-6-11(16)13(10)15(18)19/h6-9,18-19H,1-5H3

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 399-52-0 5-fluoro-1H-indole 
• 1093066-71-7 1-(tert-butyldimethylsilanyl)-5-fluoro-1H-indole 
• 5419-55-6 Triisopropyl borate 

Downstream Products

• 1449580-83-9 2-(5-fluoro-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide 

Relevant articles and documents

AURORA AND FLT3 KINASES MODULATORS

The invention provides a compound having the formula (1): and salts thereof; wherein: R1 is hydrogen or C1-2 alkyl; and R2, R3 and R4 are the same or different and each is selected from hydrogen, C1-2 alkyl, fluorine, chlorine, C1-2 alkoxy and trifluoromethyl, provided that no more than two of R2, R3 and R4 are other than hydrogen. Also provided are pharmaceutical compositions containing the compounds and their use in medicine, and in particular in the treatment of cancer.

THIENOPYRIMIDIENE DERIVATIVES AS PI3K INHIBITORS

Thienopyrimidines of formula (I) wherein W and R1 to R4 are as defined in the claims, and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PI3 kinase, over both other class Ia and class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

THIAZOLIOPYRIMIDINES AND THEIR USE AS INHIBITORS OF PHOSPHATIDYLINOSITOL-3 KINASE

Thiazolopyrimidines of formula (I): wherein W represents a thiazole ring; R1 and R2 form, together with the N atom to which they are attached, a group of the following formula (IIa): in which A is a ring system; m is 0, 1 or 2; Rsup