1093072-64-0

Basic information

• Product Name: C₃₉H₅₂N₄O
• Synonyms: C₃₉H₅₂N₄O
• CAS NO: 1093072-64-0
• Molecular Weight: 592.868
• Mol File: 1093072-64-0.mol

Chemical Properties

• CAS DataBase Reference: C₃₉H₅₂N₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₉H₅₂N₄O(1093072-64-0)
• EPA Substance Registry System: C₃₉H₅₂N₄O(1093072-64-0)

Safety Data

• Hazardous Substances Data: 1093072-64-0(Hazardous Substances Data)

Upstream product

• 4410-12-2 1-benzyl-[1,4]diazepane 
• 205812-56-2 C₂₉H₃₂O₇S₂ 

Relevant articles and documents

Pentacyclo-undecane derived cyclic tetra-amines: Synthesis and evaluation as potent anti-tuberculosis agents

As part of an ongoing effort to develop highly potent anti-tuberculosis agents, fourteen pentacyclo-undecane (PCU) tetra-amine compounds were synthesized and screened for their in vitro anti-mycobacterial activity against two TB strains, H37Rv and XDR 194 [an extensively drug-resistant strain of tuberculosis]. Using the broth macrodilution method, nitrofuranylamide based compounds (6a and 6b) showed almost similar activities against the H37Rv strain of Mycobacterium tuberculosis when compared with the control drug, ethambutol. N-Geranyl piperazine PCU (8a) and trans-trans farnesyl piperazine PCU (8b) were 3.2 and 3.7 times more potent than commercially available ethambutol. Both isoprenyl PCU tetra-amine derivatives and N-decyl piperazine PCU (9a) were highly active against the XDR 194 strain of tuberculosis with MICs in the range of 0.63-3.02 μM. Cytotoxicities (IC50) of isoprenyl based compounds (8a, 8b) and compound 9a were tested on a mammalian cell line [MDBK (Madin Darby bovine kidney epithelium)] with values of 30, 24 and 25 μM respectively.

Synthesis and NMR elucidation of novel penta-cycloundecane amine derivatives as potential antituberculosis agents

The synthesis and NMR elucidation of five novel penta-cycloundecane amine derivatives are reported. These compounds are potential antituberculosis agents. The 1H and 13C spectra showed major overlapping of methine signals of the cage skeleton making it extremely difficult to elucidate these compounds. The overlapping occurs as a result of the additions made to the carbonyl carbon (C-8/C-11) of the cage. The two-dimensional NMR technique proved to be a useful tool in overcoming this problem. All compounds reported are meso compounds thereby not only simplifying the NMR structure elucidation, but also making it indeed possible. Copyright